Actividad Antiinflamatoria de Productos Naturales

Harold Alberto GÓMEZ ESTRADA, Karina Noreica GONZÁLEZ RUIZ, José Domingo MEDINA

Resumen


Se ha reportado que algunos productos naturales presentan efectos sobre la expresión de: citoquinas proinflamatorias (IL-1b, IL-6, IL-8, GM-CSF and TNF-), enzimas mediadoras (MMP-3, MMP-13, iNOS y COX-2) y catabolitos (NO y PGE2). Esta actividad ha sido asociada con: la inactivación del NF-B, por la prevención de la fosforilación- degradación de IkBo la regulación ciertos factores de trascripción, entre otros, lo cual constituye el mecanismo de acción de tales compuestos. En este trabajo se da una visión general de la química y los diferentes modelos in vivo e in vitro de evaluación del proceso inflamatorio de compuestos de origen natural.

Palabras clave

Inflamación, Mediadores de la inflamación, Plantas medicinales, Fármacos antiinflamatorios, Productos naturales
 

Citas

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