Actividad Antiinflamatoria de Productos Naturales

Harold Alberto GÓMEZ ESTRADA, Karina Noreica GONZÁLEZ RUIZ, José Domingo MEDINA


Se ha reportado que algunos productos naturales presentan efectos sobre la expresión de: citoquinas proinflamatorias (IL-1b, IL-6, IL-8, GM-CSF and TNF-), enzimas mediadoras (MMP-3, MMP-13, iNOS y COX-2) y catabolitos (NO y PGE2). Esta actividad ha sido asociada con: la inactivación del NF-B, por la prevención de la fosforilación- degradación de IkBo la regulación ciertos factores de trascripción, entre otros, lo cual constituye el mecanismo de acción de tales compuestos. En este trabajo se da una visión general de la química y los diferentes modelos in vivo e in vitro de evaluación del proceso inflamatorio de compuestos de origen natural.

Palabras clave

Inflamación, Mediadores de la inflamación, Plantas medicinales, Fármacos antiinflamatorios, Productos naturales


Afif W, Loftus Jr EV, Faubion WA, Kane SV, Bruining DH, Hanson KA, Sandborn WJ. 2010. Clinical utility of measuring infliximab and human anti-chimeric antibody concentrations in patients with inflammatory bowel disease. Am J Gastroenterol 105: 1133 - 1139.

Aggarwal BB, Harikumar KB. 2009. Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegene-rative, cardiovascular, pulmona-ry, metabolic, autoimmune and neoplastic diseases. Int J Biochem Cell Biol 41: 40 - 59.

Aguirre MC, Delporte C, Backhouse N, Erazo S, Letelier ME, Cassels BK, Silva X, Alegría S, Negrete R. 2006. Topical anti-inflammatory activity of 2alpha-hydroxy pentacyclic triterpene acids from the leaves of Ugni molinae. Bioorg Med Chem 14: 5673 - 5677.

Akahori A. 1965. Studies on the steroidal components of domestic plants-XLIV: Steroidal sapogenins contained in Japanese Dioscorea sp. Phytochemistry 4: 97 - 106.

Akdemir Z, Kahraman C, Tatl I, Akkol E, Süntar I, Keles H. 2010. Bioassay-guided isolation of anti-inflammatory, antinociceptive and wound healer glycosides from the flowers of Verbascum mucronatum Lam. J Ethnopharmacol Epub ahead of print. doi:10.1016/j.jep.2010.05.059.(En Prensa)

Akihisa T, Yasukawa K, Oinuma H, Kasahara Y, Yamanouchi S, Takido M, Kumaki K, Tamura T. 1996. Triterpene alcohols from the flowers of Compositae and their anti-inflammatory effects. Phytochemistry 43: 1255 - 1260.

Alexandre-Moreira MS, Piuvezam MR, Araújo CC, Thomas G. 1999. Studies on the anti-inflammatory and analgesic activity of Curatella americana L. J Ethnopharmacol 67: 171 - 177.

Alvarado A, Beirana A. 2003. Pimecrolimus, opción terapéutica. Rev Cent Derm Pascua. 12: 7 - 14.

An SJ, Pae HO, Oh GS, Choi BM, Jeong S, Jang SI, Oh H, Kwon TO, Song CE, Chung HT. 2002. Inibition of TNF-alpha, IL-1 beta, and IL-6 productions and NF-kappa B Activation in Lipopolysaccharide-Activated RAW 264.7 Macrofages by Catalposide, an Iridoid Glycoside Isolated from Catalpa ovata G. Don (Bignoniaceae). Int Inmunopharmacol 2: 1173 - 1181.

Arita M, Bianchini F, Aliberti J, Sher A, Chiang N, Hong S, Yang R, Petasis N.A, Serhan CN. 2005. Stereochemical assignment, antiinflam-matory properties, and receptor for the omega-3 lipid mediator resolvin E1. J Exp Med 201: 713 - 722.

Atta A, Alkofahi A. 1998. Anti-nociceptive and anti-inflammatory effects of some Jordanian medicinal plant extracts. J Ethnopharmacol 60: 117 - 124.

Avram S, Duda-Seiman D, Svab I, Mancas S, Duda-Seiman C, Mihailescu DF. 2009. Aspirin and other non-steroidal anti-inflammatory drugs as cyclooxygenase inhibitors: state of the art, barriers and perspectives. Curr Comp Aided Drug Design 5: 1 - 12.

Baehner R, Boxer L, Davis J. 1976. The biochemical basis of nitroblue tetrazolium reduction in normal human and chronic granulomatous disease polymorphonuclear leukocytes. Blood 48: 309 - 313.

Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA. 1990. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci 87: 1620 - 1624.

Bergström S, Ryhage R, Samuelsson B y Sjövall J. 1963. Prostaglandins and related factors.15. The structures of prostaglandin E1, F1a, and F1b. J Biol Chem 238: 3555 - 3564.

Bhattaram VA, Graefe U, Kohlert C, Veit M, Derendorf H. 2002. Pharmacokinetics and Bioavailability of Herbal Medicinal Products. Phytomedicine 9: 1 - 33. Böhler T, Nolting J, Gurragchaa P, Lupescu A, Neumayer HH, Budde K, Kamar N, Klupp J. 2008. Tabebuia avellanedae extracts inhibit IL-2-independent T-lymphocyte activation and proliferation. Transplant Immunol 18: 319 - 323.

Bozin B, Mimica-Dukic N, Samojlik I, Goran A, Igic R. 2008. Phenolics as antioxidants in garlic (Allium sativum L., Alliaceae). Food Chem 111: 925 - 929.

Bremner P, Heinrich M. 2002. Natural products as targeted modulators of the nuclear factor-kappaB pathway. J Pharm Pharmacol 54: 453-72.

Brinker AM, Ma J, Lipsky PE, Raskin I. 2007. Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae). Phytochemistry 68: 732 - 766.

Bull AW. 2003. The role of peroxisome proliferator-activated receptor gamma in colon cancer and inflammatory bowel disease. Arch Pathol Lab Med 127: 1121 - 1123.

Byeon SE, Chung JY, Lee YG, Kim BH, Kim KH, Cho JY. 2008. In vitro and in vivo anti-inflammatory effects of taheebo, a water extract from the inner bark of Tabebuia avellanedae. J Ethnopharmacol 119: 145 - 152.

Castardo JC, Prudente AS, Ferreira J, Guimarães C, Monached FD, Filho VC, Otuki MF, Cabrini DA. 2008. Anti-inflammatory effects of hydroalcoholic extract and two biflavonoids from Garcinia gardneriana leaves in mouse paw oedema. J Ethnopharmacol 118: 127 - 135.

Cespedes C, Alarcón J, Avila J, Nieto A. 2010. Actividad anti-inflamatoria de Aristotelia chilensis Mol. (Stuntz) (Elaeocarpaceae). Bol Latinoam Caribe Plant Med Aromat 9: 127 - 135.

Chakraborty A, Devi R, Rita S, Sharatchandra K. and Singh T. 2004. Preliminary studies on antiinflammatory and analgesic activities of Spilanthes acmella in experimental animal models. Indian J Pharmacol 36: 148 - 150.

Changa DM, Kuob SY, Laib JH, Changb ML. 1999. Effects of anti-rheumatic herbal medicines on cellular adhesion molecules. Ann Rheum Dis 58: 366 - 371.

Cheeke PR, Piacente S, Oleszek W. 2006. Anti-inflammatory and anti-arthritic effects of yucca schidigera: A review. J Inflammation 3: 1 - 7.

Chen YC, Shen SC, Chen LG, Lee TI, Yang LL. 2001. Wogonin, baicalin and baicalein. Inhibition of indicible nitric oxide synthase anhibitors and lipopolysacchaaride. Biochem Pharmacol 61: 1417 - 1427.

Cheng AC, Jian CB, Huang YT, Lai CS, Hsu PC, Pan MH. 2007. Induction of apoptosis by Uncaria tomentosa through reactive oxygen species production, cytochrome c release, and caspases activation in human leukemia cells. Food Chem Toxicol 45: 2206 - 2218.

Cho JY, Baik KU, Yoo ES, Yoshikawa K, Park MH. 2000. In vitro anti-inflammatory effects of neolignan woorenosides from the rhizomes of Coptis japonica. J Nat Prod 63: 1205 - 1209.

Cho JY, Park J, Kim PS, Yoo ES, Baik KU, Park MH.2001a. Savinin, a lignan from Pterocarpus santalinus inhibits tumor necrosis factor-alpha production and T cell proliferation. Biol Pharm Bull 24: 167 - 171.

Cho JY, Park J, Yoo ES, Yoshikawa KU, Baik K, Lee J, Park MH. 1998. Inhibitory effect of lignans from the rhizomes of Coptis japonica var. Dissecta on tumor necrosis factor-alpha production in lipopolysaccharide-stimulated RAW 264.7 cells. Arch Pharm Res 21: 12 - 16.

Cho JY, Yoo ES, Baik K, Park M, Han B. 2001b. In vitro Inhibitory Effect of protopanaxadiol ginsenosides on tumor necrosis factor alpha (TNF) production and its modulation by known THF-alpha antagonists. Planta Medica 67: 213 - 218.

Cirelli MG. 1967. Five years of clinical experience with bromelains in therapy of edema and inflammation in postoperative tissue reaction, skin infections and trauma. Clin Med 74: 55 - 59.

Cisneros FJ, Jayo M. 2006. Aqueous extract of Uncaria tomentosa (cat's claw) ameliorates ozone induced inflammation. First International Symposia about Pharmaco-logy of Natural Products and First BLACPMA. Varadero, Cuba. November 20-24, 2006.

Colombel JF, Sandborn WJ, Reinisch W, Mantzaris GJ, Kornbluth A, Rachmilewitz D, Lichtiger S, D’Haens G, Diamond RH, Broussard DL, Tang KL, Van der Woude CJ, Rutgeerts P. 2010. Infliximab, azathioprine or combination therapy for Crohn disease. New Eng J Med 362: 1383 - 1395.

Danese S, Fiorino G, Vetrano S, Rando G, Pagano N, Romeo F, Omodei P, Repici A, Rutella S, Malesci A. 2009. Infliximab inhibits mucosal pathological angiogenesis in Crohn’s disease. Grastroenterology 136: 558.

De Bie CI, Hummel TZ, Kindermann A, Kokke FTM, Damen GM, Kneepkens CMF, Van Rheenen PF, Schweizer JJ, Hoekstra JH, Norbruis QF, Tjon a Ten WE, Vreugdenhil AC, Deckers-Kochen JM, Gijsbers CFM, Escher JC, De Ridder L. 2011. The duration of effect of infliximab maintenance treatmen in pediatric Crohn’s disease is limited. Alim Pharmacol Ther 33: 243 - 250.

De Young LM, Kheifets JB, Ballaron SJ, Young JM. 1989. Edema and cell infiltration in the phorbol ester-treated mouse ear are temporally separated and can be differentially modulated by pharmacologic agents. Agents Actions 26: 335 - 341.

Deepa N, Kaur C, George B, Singh B, Kapoor HC. 2007. Antioxidant constituents in some sweet pepper (Capsicum annuum L.) genotypes during maturity. J Food Sc Technol 40: 121 - 129.

Dupuy O, Murillo R, Bonilla J. 2008. Actividad supresora del millerenólido sobre células mononucleares de sangre periférica humana. Rev Med Chile. 136: 64 - 72.

El-Ghorab A, El-Massry KF, Shibamoto T. 2007. Chemical Composition of the Volatile Extract and Antioxidant Activities of the Volatile and Nonvolatile Extracts of Egyptian Corn Silk (Zea mays L.). J Agric Food Chem 55: 9124 - 9127.

Esch M. 2000. Investigation of the efficacy of a poly-vinil-pyrrolidone-iodine complex for treatment of digital dermatitis in dairy cows (poster) Proceeding XI International Symposium on dissorders of the ruminant digit. Parma. Italy.

Fahey AJ, Adrian Robins R, and Constantinescu CS. 2007. Curcumin modulation of IFN- and IL-12 signalling and cytokine induction in human T cells. J Cell Mol Med 11: 1129 - 1137.

Fazio AL, Ballén D, Cesari IM, Abad MJ, Arsenak M. Taylor P. 2008. An ethanolic extract of Uncaria tomentosa reduces inflammation and B16-BL6 melanoma growth in C57BL/6 mice. Bol Latinoam Caribe Plant Med Aromat 7: 217 - 224.


Feagan BG, McDonald JW, Panaccione R, Enns RA, Bernstein CN, Ponich TP, Bourdages R, MacIntoch DG, Dallaire C, Cohen A, Fedorak RN, Pare P, Bitton A, Saibil F, Anderson F, Donner A, Wong CJ, Zou GY, Vandervoort MK, Hopkins M, Greenberg GR. 2010. Methotrexate for the prevention of antibodies to infliximab in patients with Crohn’s disease. Gastroenterology 138: 167 – 168.

Fernández F, Torres M. 2006. Evaluation of Pluchea carolinensis extracts as antioxidants by the epinephrine oxidation method. Fitoterapia 77: 221 - 226.

Fiebich BL, Chrubasik S. 2004. Effects of an ethanolic Salix extract on the release of selected inflammatory mediators in vitro. Phytomedicine 11: 135 - 138.

Fonseca FA, França CN, Póvoa RM, Izar MC. 2010. Estatinas y accidente cerebrovascular: posibles mecanismos de acción de la protección neurovascular. Rev Neurol 51: 551 - 560.

Fridovich I. 1997. Superoxide anion radical (O2-), superoxide dismutases, and related matters. J Biol Chem 272: 18515 - 18517.

Fujiwara A, Mori T, Iida A, Ueda S, Hano Y, Nomura T, Tokuda H, Nishino H. 1998. Antitumor promoting naphthoquinones from Catalpa ovata. J Nat Prod 61: 629 - 632.

Funk C. 2001. Prostaglandins and leukotrienes: Advances in eicosanoid biology. Science 294: 1871 - 1875.

Galvez J, Gracioso JdS, Camuesco D, Vilegas W, Monteiro Souza Brito AR, Zarzuelo A. 2006. Intestinal antiinflammatory activity of a lyophilized infusion of Turnera ulmifolia in TNBS rat colitis. Fitoterapia 77: 515 - 520.

Gautam R, Jachak SM, Saklani A. 2011. Anti-inflammatory effect of Ajuga bracteosa Wall Ex Benth. mediated through cyclooxygenase (COX) inhibition. J Ethnopharmacol 133: 928 - 930.

Germosén-Robineau L. 2005. Farmacopea Vegetal Caribeña. 2a. Ed. Editorial Universitaria, León-Nicaragua. pp. 352-357.

Gerritsen ME, Carley WW, Ranges GE, Shen CP, Phan SA, Ligon GF, Perry CA. 1995. Flavonoids Inhibit Cytokine-induced Endothelial Cell Adhesion Protein Gene Expression. Am J Pathol 147: 278 - 292.

Gilmore TD. 2006. Introduction to NF-B: players, pathways, perspectives. Oncogene 25: 6680 - 6684.

Gómez HA, Gaitán R, Franco LA, Mercado JE, Rodríguez E, Méndez D, Díaz F. 2005. Flora Medicinal del Norte de Bolívar, Colombia: Un Enfoque Cuantitativo y Evaluación Preliminar de la Actividad Antiinflamatoria de Algunas Especies Promisorias. III Encuentro Nacional de Química de Medicamentos. (UCV. Caracas, Venezuela. 21 - 23 de Junio).

Goodman A, Hardman J, Limbird L. 2001. Las Bases Farmacológicas de la Terapéutica. 10a. Sección IV, pp 697 - 742. Ed. Mc Graw Hill. New York.

Grases F., March J. G., Ramis M, Costa-Bauzá A.. 1993. The influence of Zea mays on urinary risk factors for kidney stones in rats. Phytother Res 7: 146 - 149.

Grisham MB, Jourd’Heuill D, Wink, DA. 1999. Nitric oxide. I. Physiological chemistry of nitric oxide and its metabolites: implications in inflammation. Am J Physiol Gastrointest Liver Physiol 276: G315 - G321.

Guarrera PM. 2005. Traditional phytotherapy in Central Italy (Marche, Abruzzo, and Latium). Fitoterapia 76: 1 - 25.

Gutiérrez R, Mitchell S, Solis R. 2008. Psidium guajava: A review of its traditional uses, phytochemistry and pharmacology. J Ethnopharmacol 117: 1 - 27.

Habeeb F, Stables G, Bradbury F, Nong S, Cameron P, Plevin R, Ferro VA. 2007. The inner gel component of Aloe vera suppresses bacterial-induced pro-inflammatory cytokines from human immune cells. Methods 42: 388 - 393.

Han Q, Lu Y, Zhang LI, Zheng QI, Sun H. 2004. Novel ent-kaurane dimers from Isodon rubescens var. rubescens Tetrahedron Lett 45: 2833 - 2837.

Handa S, Chawla AS, Sharma AK. 1992. Plants with anti-inflammatory cctivity. Fitoterapia 63: 3 - 31.

Hardin SR. 2007. Cat's claw: An Amazonian vine decreases inflammation in osteoarthritis. Complement Ther Clin Pract 13: 25 - 28.

Hasegawa T, Takano F, Takata T, Niiyama M, Ohta T. 2008. Bioactive monoterpene glycosides conjugated with gallic acid from the leaves of Eucalyptus globules. Phytochemistry 69: 747 - 753.

Hebert, MD, Kristyn Anne Warken KA, Robert Cherill R. 2001. Pimecrolimus cream 1%: A new development in nonsteroid topical treatment of inflammatory skin diseases. Sem Cutaneous Med Surg 20: 260 - 267.

Hetter GP. 2000. An examination of the Phenol-Croton oil Peel: Part I. Dissecting the formula. Plastic Reconstr Surg 105: 227 - 239.

Hodge G, Nairn J, Holmes M, Reynolds PN, Hodge S. 2007. Increased intracellular T helper 1 proinflammatory cytokine production in peripheral blood, bronchoalveolar lavage and intraepithelial T cells of COPD subjects. Clin Exp Immunol 150: 22 - 29.

Howell L, Kochhar K, Saywell R, Zollinger T, Koehler J, Mandzuk C, Sutton B, Sevilla-Martiz J, Allen D. 2006. Use of herbal remedies by hispanic patients: Do they inform their physician? J Am Board Fam Med 19: 566 - 578.

Huang FC, Chang WK, Moriarty KJ, Zhang DC, Chang M, He W, Yu KT, Zilberstein A. 1988. Novel cytokine release inhibitors. Part I: triterpenes. Biorg Med Chem Lett 8: 1883 - 1886.

Huang T, Tran V, Duke R, Tan S, Chrubasik S, Roufogalis B, Duke C. 2006. Harpagoside suppresses lipopolysaccharide-induced iNOS and COX-2 expression through inhibition of NF-κB activation. J Ethnopharmacol 104: 149 - 155.

Imaizumi T, Arikawa T, Sato T, Uesato R, Matsumiya T, Yoshida H, Ueno M, Yamasaki S, Nakajima T, Hirashima M, Sakata K, Ishibashi Y, Toh S, Ohyama C, Satoh K. 2008. Involvement of retinoic acid-inducible gene-I in inflammation of rheumatoid fibroblast-like synoviocytes. Clin Exp Immunol 153: 240 - 244.

Inngjerdingen KT, Debes SC, Inngjerdingen M, Hokputsa S, Harding SE, Rolstad B, Michaelsen TE, Diallo D, Paulsen BS. 2005. Bioactive pectic polysaccharides from Glinus oppositifolius (L.) Aug. DC., a Malian medicinal plant, isolation and partial characterization. J Ethnopharmacol 101: 204 - 214.

Janaki S, Vijayasekaran V, Viswanathan S, Balakrishna K. 1999. Anti-Inflammatory Activity of Aglaia roxburghiana var. Beddomei extract and triterpenes Roxburghiadiol A and B. J Ethnopharmacol 67: 45 - 51.

Kang BY, Chung SW, Kim TS. 2001. Inhibition of interleukin-2 production in lipopolysaccha-ride-activated mouse macrophages by hypericin, an active component of Hypericum perforatum .Planta Medica 67: 364 - 366.

Kardošová A, Machová E. 2006. Antioxidant activity of medicinal plant polysaccharides. Fitoterapia 77: 367 - 373.

Karima R, Matsumoto S, Higashi H, Matsushima K. 1999. The molecular pathogenesis of endotoxic shock and organ failure. Mol Med Today 5: 123 - 132.

Kaszkin M, Beck KF, Koch E, Erdelmeier C, Kusch S, Pfeilschifter J, Loew D. 2004. Downregulation of iNOS expression in rat mesangial cells by special extracts of Harpagophytum procumbens derives from harpagoside-dependent and independent effects. Phytomedicine 11: 585 - 595.

Katz JA, Antoni C, Keenan GF, Smith DE, Jacobs SJ, Lichtenstein GR. 2004. Outcome of pregnancy in women receiving infliximab for the treatment of Crohn’s disease and rheumatoid arthritis. Am J Gastroenterol 99: 2385 - 2392.

Kim S, Kim Y, Kim JE, Cho KH, Chung JH. 2008. Berberine inhibits TPA-induced MMP-9 and IL-6 expression in normal human keratinocytes. Phytomedicine 15: 340 - 347.

Kubo M, Matsuda H, Tanaka M, Kimura Y, Okuda H, Higashino M, Tani T, Namba K, Arichi S. 1984. Studies on Scutellariar radix: VII. Anti-arthritic and anti-inflammatory actions of methanolic extract and flavonoids components from Scutellariae radix. Chem Pharm Bull 32: 2724 - 2729.

Kundu JK, Mossanda KS, Na HK, Surh YJ. 2005. Inhibitory effects of the extracts of Sutherlandia frutescens (L.) R. Br. and Harpagophytum procumbens DC. on phorbol ester-induced COX-2 expression in mouse skin: AP-1 and CREB as potential upstream targets. Cancer Lett 218: 21 - 31.

Kuti JO, Konoru HB. 2004. Antioxidant capacity and phenolic content in leaf extracts of tree spinach (Cnidoscolus spp.). J Agric Food Chem 52: 117 - 121.

Kuti JO, Konoru HB. 2006. Cyanogenic glycosides content in two edible leaves of tree spinach (Cnidoscolus spp.). J Food Composition Anal 19: 556 - 561.

Lagarto A, Silva R, Guerra I, Iglesias L. 2001. Comparative study of the assay of Artemia salina L. and the estimate of the medium lethal dose (LD50 value) in mice, to determine oral acute toxicity of plant extracts. Phytomedicine 8: 395 - 400.

Lambev I, Markov M, Pavlova N. 1981. Study of the antiinflammatory and capillary restorative activity of a dispersed substance from Plantago major L. Probl Vatr Med 9: 162 - 169.

Lee JH, Lee JY, Kang HS, Jeong CH, Moon H, Whang WK, Kim CJ, Sim SS. 2006. The effect of acteoside on histamine release and arachidonic acid release in RBL-2H3 mast cells. Arch Pharm Res 29: 508 - 513.

Lee JY, Woo ER, Kang KW. 2005. Inhibition of lipopolysaccharide-inducible nitric oxide synthase expression by acteoside through blocking of AP-1 activation. J Ethnopharmacol 97: 561 - 566.

León JE, Rosales VP, Rosales R, Pavón V. 1999. Actividad antiinflamatoria y cicatrizante del ungüento rectal de Aloe vera L. (sábila). Rev Cub Plant Med 3: 106 - 109.

Lesjak M, Beara I, Orcić D, Anačkov G, Balog K, Francišković M, Mimica-Duki N. 2011. Juniperus sibirica Burgsdorf as a novel source of antioxidant and anti-inflammatory agents. Food Chem 124: 850 - 856

Liu CH, Xue YR, Ye YH, Yuan FF, Liu JY, Shuang JL. 2007. Extraction and characterization of antioxidant compositions from fermented fruit juice of Morinda citrifolia (Noni). Agric Sc China. 6: 1494 - 1501.

Liu K, Gualano RC, Hibbs ML, Anderson GP, Bozinovski S. 2008. Epidermal growth factor receptor signaling to Erk1/2 and STATs Control the intensity of the epithelial inflammatory responses to rhinovirus infection. J Biol Chem 283: 9977 - 9985.

Lügering A, Schmidt M, Lügering N, Pauels HG, Domschke W, Kucharzik T. 2001. Infliximab induces apoptosis in monocytes from patients with chronic active Crohn’s disease by using a caspase-dependent pathway. Gastroenterolo-gy 121: 1145 - 1157.

Manna SK, Mukhopadhyay A, Van NT, Aggarwal BB. 1999. Silymarin suppresses TNF-induced activation of NF-kappa B, c-Jun N-terminal kinase, and apoptosis. J Immunology 163: 6800 - 6809.

Matsuda H, Yoshikawa M, Linuma M, Kobo M. 1998. Antinociceptive and antiinflammatory activi-ties of limonin isolated from the fruits of Evodia rutaecarpa Var. Bodinieri. Planta Medica 64: 339 - 342.

Moffatt MF. 2008. Genes in asthma: new genes and new ways. Curr Opin Allergy Clin Immunol 8: 411 - 417.

Mosmann T. 1983. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65: 55 – 63.

Mueller C, Weaver V, Vanden H, August A, Cantorna M. 2003. Peroxisome proliferator-activated receptor gamma ligands attenuate immunological symptoms of experimental allergic asthma. Arch Biochem Biophys 418: 186 - 196.

Nag Chaudhuri AK, Karmakar S, Roy D, Pal S, Pal M, Sen T. 2005. Anti-inflammatory activity of Indian black tea (Sikkim variety). Pharmacol Res 51: 169 - 175.

Nair MG, Sommerville J, Burke BA. 1989. Phenyl propenoids from roots of Piper auritum. Phytochemistry 28: 654 - 655.

Nardi GM, Siqueira JM, Monache FD, Pizzolatti MG, Ckless K, Ribeiro do Valle RM. 2007. Antioxidant and anti-inflammatory effects of products from Croton celtidifolius Bailon on carrageenan-induced pleurisy in rats. Phytomedicine 14: 115 - 122.

Nathan C. 2002. Points of control in inflammation. Nature 420: 846 - 852.

Nathan CF. 1987. Neutrophil activation on biological surfaces. Massive secretion of hydrogen peroxide in response to products of macrophages and lymphocytes. J Clin Invest 80: 1550 - 1560.

Nelson NA. 1974. Prostaglandin nomenclature. J Med Chem 17: 911 - 918.

Newman DJ, Cragg GM, Snader KM. 2003. Natural products as sources of new drugs over the period 1981 - 2002. J Nat Prod 66: 1022 - 1037.

Olajide OA, Okpako DT, Makinde JM. 2003. Anti-inflammatory properties of Bridelia ferruginea stem bark Inhibition of lipopolysaccaride-induced septic shock and vascular permeability. J Ethnopharmacol 88: 221 - 224.

Organización Mundial de la Salud. 2002. Estrategia de la OMS sobre Medicina Tradicional 2002-2005. WHO/EDM/TRM/ 2002.1. Ginebra.

Ortega T, Carretero MT, Pascual E, Villar AM 1996. Antiinflamatory activity of ethanolic extracts of plants used in traditional medicine in Ecuador. Phytoter Res 10: S121 - S122.

Patel H, Belvisi M, Bishop D, Yacoub M, Mitchell J. 2003. Activation of peroxisome proliferator-activated receptors in human airway smooth muscle cells has a superior anti-inflammatory profile to corticosteroids: relevance for chronic obstructive pulmonary disease therapy. J Immunology 170: 2663 - 2669.

Patthamakanokporn O, Puwastien P, Nitithamyong A, Sirichakwal PP. 2008. Changes of antioxidant activity and total phenolic compounds during storage of selected fruits. J Food Compos Anal 21: 241 - 248.

Payá M, Ferrándiz ML, Sanz MJ, Bustos G, Blasco R, Rios JL, Alcaraz MJ. 1993. Study of the antioedema activity of some seaweed and sponge extracts from the mediterrânea coast in mice. Phytother Res 7: 159 - 162.

Prieto JM, Recio MC, Giner RM, Máñez S, Massmanian A, Waterman PG, Ríos JL. 1996. Topical anti-inflammatory lignans from Haplophyllum hispanicum. Z Naturforsch C 51: 618 - 622.

Rassoul F, Salvetter J, Reissig D, Schneider W, Thiery J, Richter V. 2006. The influence of garlic (Allium sativum) extract on interleukin 1α-induced expression of endothelial intercellular adhesion molecule-1 and vascular cell adhesion molecule-1. Phytomedicine 13: 230 - 235.

Recio MC, Giner RM, Máñez S, Gueho J, Julien HR, Hostettmann K, Ríos JL. 1995. Investigations on the steroidal anti-inflammatory activity of triterpenoids from Diospyros leucomelas. Planta Medica 61: 9 - 12.

Ren HX, Wang ZL, Chen X, Zhu YL. 1999. Antioxidative responses to different altitudes in Plantago major. Environ Exp Bot 42: 51 - 59.

Renda G, Zurro M, Romano M, De Caterina R. 2010. Aspirin-triggered lipoxin in patients treated with aspirin and selective vs. nonselective COX-2 inhibitors. Br J Clin Pharmacol 69: 303 - 306.

Ricart E, Panaccione R, Loftus EW, Tremaine WJ, Sandborn WJ. 2001. Infliximab for Crohn’s disease in clinical practice at the Mayo Clinic: the first 100 patients. Am J Gastroenterol 92: 722 - 729.

Ringbom T, Segura L, Noreen Y, Perera P, Bohlin L. 1998. Ursolic acid from Plantago major, a selective inhibitor of cyclooxygenase-2 catalyzed prostaglandin biosynthesis. J Nat Prod 61: 1212 - 1215.

Ríos JL, Recio MC, Giner RM, Máñez S. 2004. Métodos de estudio in vivo de extractos y productos antiinflamatorios. En Nuevas Fuentes de Antioxidantes Naturales (Rosas A, ed.), CYTED, Caracas. pp. 107 - 116.

Rogerio AP, Fontanari C, Borducchi E, Keller AC, Russo M, Soares EG, Albuquerque DA, Faccioli LH. 2008. Anti-inflammatory effects of Lafoensia pacari and ellagic acid in a murine model of asthma. Eur J Pharmacol 580: 262 - 270.

Romier-Crouzet B, Van De Walle J, During A, Joly A, Rousseau C, Henry O, Larondelle Y, Schneider YJ. 2009. Inhibition of inflammatory mediators by polyphenolic plant extracts in human intestinal Caco-2 cells. Food ChemToxicol 47:1221 - 1230.

Rosales V, Gross M, Rosales R, García R, León J, Vidal M. 1999. Evaluación farmacológica de Pluchea carolinensis Jacq (salvia de playa) en animales de experimentación. Rev Cub Plant Med 3: 65 - 67.

Rusak G, Komes D, Likić S, Horžić D, Kovač M. 2008. Phenolic content and antioxidative capacity of green and white tea extracts depending on extraction conditions and the solvent used. Food Chem 110: 852 - 858.

Safayhi H, Sailer ER.1997. Anti-inflammatory actions of pentacyclic triterpenes. Planta Medica 63: 487 - 493.

Sandborn WJ, Hanauer SB. 2002. Infliximab in the treatment of Crohn`s disease: a user`s guide for clinicians. Am J Gastroenterol 97: 2062 - 2972.

Sandoval M, Charbonnet RM, Okuhama NN, Roberts J, Krenova Z, Trentacosti AM, Miller MJS. 2000. Cat’s Claw Inhibits TNF Production and Scavenges Free Radicals: Role in Cyto-protection. Free Rad Biol Med 29: 71 - 78.

Sandoval M, Thompson JH, Zhang XJ, Liu X, Mannick EE, Sandowska-Krowicka H, Charbonnet RM, Clark DA, Miller MJS. 1998. Antiinflammatory actions of cat's claw: the role of NF-kappa B. Aliment Pharmacol Ther 12:1279 - 1289.

Santoro A, Bianco G, Picerno P, Aquinoa RP, Autore G, Marzocco S, Gazzerro P, Lioi MB, Bifulco M. 2008. Verminoside- and verbascoside-induced genotoxicity on human lymphocytes: Involvement of PARP-1 and p53 proteins. Toxicol Lett 178: 71 - 76.

Schinella G, Tournier H, Zaidenberg A. 2008. On the preclinical anti-trypanosomal, anti-inflam-matory and toxicological activities of H. linifolium (L.) G. Don and its diphyllin derivatives. Bol Latinoam Caribe Plant Med Aromat 7: 226 - 229.

Schuler W, Sedrani R, Cottens S, Häberlin B, Schulz M, Schuurman HJ, Zenke G, Zerwes HG, Schreie, MH. 1997. SDZ RAD, a new rapamycin derivative: pharmacological properties in vitro and in vivo. Transplantation 64:36 - 42

Setty AR, Sigal LH. 2005. Herbal Medications Commonly Used in the Practice of Rheumatology: Mechanisms of Action, Efficacy, and Side Effects. Semminars Arthritis Rheum 34: 773 - 784.

Silvester J, Liacini A, Li W, Dehnade F, Zafarullah M. 2001. Tripterygium wilfordii HooK F extract suppresses proinflamatory citoquine-induced expression of Matrix metalloproteinase genes in articular chondrocytes by inhibiting activating protein-1 and nuclear factor-kB activities. Mol Pharmacol 59: 1196 - 1205.

Siguel EN., Lerman RH. 1996. Prevalence of essential fatty acid deficiency in patients with chronic gastrointestinal disorders. Metabolism 45: 12 - 23.

Sirtori CR. 2001. Aescin: pharmacology, pharmaco-kinetics and therapeutic profile. Pharmacol Res 44: 183 - 193.

Smith WL, Garavito RM, DeWitt DL. 1996. Prostaglandin endoperoxide H synthases (cyclooxygenase)-1 and 2. J Biol Chem 271: 33157 - 33160.

Spencer CM, Goa KL and Gillis JC. 1997. Tacrolimus. An update of its pharmacology and clinical efficacy in the management of organ transplantation. Drugs 54: 925 - 975.

Suárez A, Blanco Z, Compagnone RS, Salazar-Bookaman M, Zapata V, Alvarado C. 2006. Anti-inflammatory activity of Croton cuneatus aqueous extract. J Ethnopharmacol 105: 99 - 101.

Suárez AI, Compagnone RS, Salazar-Bookaman MM, Tillett S, Delle Monache F, Di Giulio C, Bruges G. 2003. Antinoniceptive and Anti-inflamatory effects of Croton malambo bark aqueous extract. J Ethnopharmacol 88: 11 - 14.

Sughisita E, Amagaya S, Ogihara Y. 1981 Anti-inflammatory testing methods: comparative evaluation of mice and rats. J Pharmacol Biodyn 4: 565 - 575.

Sujatha R, Srinivas L. 1995. Modulation of lipid peroxidation by dietary components. Toxicology in Vitro 9: 231 - 236.

Szekanecz Z, Szucs G, Szanto S, Koch AE. 2006. Chemokines in rheumatic diseases. Curr Drug Targets 7: 91 - 102.

Tao X, Lipsky PE. 2000. The Chinese anti-inflammatory and immunosuppressive herbal remedy Tripterygium wilfordii Hook.f. Rheum Dis Clin North Am 26: 29 - 50.

Tavares A, Gonçalves M, Cruz M, Cavaleiro C, Lopes M, Canhoto J, Salgueiro L. 2010. Essential oils from Distichoselinum tenuifolium: Chemical composition, cytotoxicity, antifungal and anti-inflammatory properties. J Ethnopharmacol 130: 593 - 598

Tham DM, Wang YX, Rutledge JC. 2003. Modulation of vascular inflammation by PPARs. Drug News Perspect 16: 109 - 116.

Thuong PT, Dao TT, Pham THM, Nguyen PH, Le TVT, Lee KY, Oh WK. 2009. Crotonkinensins A and B, diterpenoids from the vietnamese medicinal plant Croton tonkinensis. J Nat Prod 72: 2040 - 2042.

Ulubelen A, Öztürk M. 2008. Alkaloids, coumarins and lignans from Haplophyllum species. Rec Nat Prod 2: 54 - 69.

Van Hogezand RA, Witte AM, Veenendaal RA, Wagtmans MJ, Lamers CB. 2001. Proximal Crohn’s disease: review of the clinicopathologic features and therapy. Inflamm Bowel Dis 7: 328 - 337.

Vázquez B, Avila G, Segura D, Escalante B. 1996. Antiinflammatory activity of extracts from Aloe vera gel. J Ethnopharmacol 55: 69 - 77.

Vazquez G, Fontenla E, Santos J, Freire MS, Gonzalez-Alvarez J, Antorrena G. 2008. Antioxidant activity and phenolic content of chestnut (Castanea sativa) shell and eucalyptus (Eucalyptus globulus) bark extracts. Industrial Crops Prod. 28: 279 - 285.

Vera V, Villanueva V, Samper A, Alarcón M, De Andrés J. 2007. Ziconotide: una alternativa innovadora en el dolor crónico neuropático intenso. Rev Neurol 45: 665 - 669

Victoria MC, Morón F, Morejón Z, Martínez MJ, López M. 2006. Tamizaje fitoquímico, actividad antiinflamatoria y toxicidad aguda de extractos de hojas de Annona squamosa L. [en línea]. Rev Cub Plant Med 11(1):

Wadsworth TL, McDonald TL, Koop DR. 2001. Effects of Ginkgo biloba extract (EGb 761) and quercetin on lypopolysaccharide-induced signalling pathways involved in the release of tumor necrosis factor-alpha. Biochem Pharmacol 62: 963 - 974.

Werner T, Shkoda A, Haller D. 2007. Intestinal epithelial cell proteome in IL-10 deficient mice and IL-10 receptor reconstituted epithelial cells: impact on chronic inflammation. J Proteo Res 6: 3691 - 3704.

West B., Deng S, Palu AK, Jensen CJ. 2009. Morinda citrifolia Linn. (Rubiaceae) leaf extracts mitigate UVB-induced erythema. J Nat Med 63: 351 - 354.

Winter CA, Porter CA. 1957. Effect of alteration in side chain uppon antiinflamatory and liver glycogens activities of hydrocortisone esters. J Am Pharm Sc 46: 515 - 519.

Wu CF, Bi XL, Yang JY, Zhan JY, Dong YX, Wang JH, Wang JM, Zhang R, Li X. 2007. Differential effects of ginsenosides on NO and TNF- production by LPS-activated N9 microglia. Int Immunopharmacol 7: 313 - 320.

Xagorari A, Papapetropoulos A, Mauromatis A, Economou M, Fotsis T, Roussos C. 2001. Luteolin inhibits and endotoxin-stimulated phosphorylation cascade and proinflamma-tory cytokine production in macrophages. J Pharmacol Exp Ther 296: 181 - 187.

Xiong Q, Tezuka Y, Kaneko T, Li H, Tran LQ, Hase K, Namba T, Kadota S. 2000. Inhibition of nitric oxide by phenylethanoids in activated macrophages. Eur J Pharmacol 400: 137 - 144.

Yunes RA, Filho VC, Ferreira J, Calixto JB. 2005. The use of natural products as sources of new analgesic drugs. Stud Nat Prod Chem 30: 191 - 212.

Zhou LF, Zhang MS, Hu AH, Zhu Z, Yin KS. 2008. Selective blockade of NF-κB by novel mutated IκBα suppresses CD3/CD28-induced activation of memory CD4 T cells in asthma. Allergy 63: 509 - 517.

Zhu Z, Ma K, Ran X, Zhang H, Zheng C, Han T, Zhang Q, Qin L. 2011. Analgesic, anti-inflammatory and antipyretic activities of the petroleum ether fraction from the ethanol extract of Desmodium podocarpum. J Ethnopharmacol 133: 1126 - 1131.

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