1.2.2.Synthesis, crystal structure and in vitro anti-tumor activity of dibutyltin complex of 2,4-dichloro-5-fluorobenzoic acid
Abstract
The dibutyltin complex of 2,4-dichloro-5-
fluorobenzoic acid, [(2,4-Cl2 -5-FC6 H2 C(O)OSnBu2 )2 O]2 (Bu =
CH2 CH2 CH2 CH3 ) (1 ), has been synthesized and characterized
by elemental analysis, FT-IR, 119 Sn NMR spectroscopy, and Xray
single crystal diffraction. Compound 1 is a centrosymmetric
dimmer with two distinct types of carboxylate moieties and tin
atoms with distorted trigonal bipyramidal geometries. The in
vitro anti-tumor activity of 1 against two human tumor cell lines
was found to be higher than that for cis-platin [cis diaminedichloroplatinum(
II)] used clinically.
Supporting information : FT-IR, 119 Sn NMR, X-Ray, Proliferation
inhibitory rate, Cif file.
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How to Cite
Yue Xin, Laijin Tian, M. L. L. W. Z. Z. (1). 1.2.2.Synthesis, crystal structure and in vitro anti-tumor activity of dibutyltin complex of 2,4-dichloro-5-fluorobenzoic acid. Communications in Inorganic Synthesis, 1(2). https://doi.org/10.21060/cis.v1i2.1998
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