Synthesis, characterization and antibacterial activity of cyclohexyltin N-(salicylidene)valinates

  • Laijin Tian Key Laboratory of Natural Products and Pharmaceutical Intermediates, Qufu Normal University, Qufu 273165, China.
  • Xiaowen Shi Key Laboratory of Natural Products and Pharmaceutical Intermediates, Qufu Normal University, Qufu 273165, China.
  • Guochao Kong Key Laboratory of Natural Products and Pharmaceutical Intermediates, Qufu Normal University, Qufu 273165, China.
  • Lin Liu Key Laboratory of Natural Products and Pharmaceutical Intermediates, Qufu Normal University, Qufu 273165, China.
  • Hong Gao Key Laboratory of Natural Products and Pharmaceutical Intermediates, Qufu Normal University, Qufu 273165, China.
  • Xue GaO Key Laboratory of Natural Products and Pharmaceutical Intermediates, Qufu Normal University, Qufu 273165, China.

Abstract

Abstract: Two new cyclohexyltin N-(salicylidene)valinates, [2-HOC6H4CH=NCH(CH(CH3)2)COO]SnCy3 (1) and [2-OC6H4CH=NCH(CH(CH3)2)COO]SnCy2 (2) (Cy = cyclohexyl), have been synthesized and characterized by elemental analysis, IR, and 1H NMR. The crystal structure of 2 has been determined by X-ray single crystal diffraction. In the complexes, the carboxylate is monodentate. Complex 1 is a four-coordinated tin compound, and 2 has a distorted trigonal bipyramidal geometry with the axial locations occupied by one carboxylate oxygen and a phenolic oxygen of the ligand. Bioassay results show that 1 and 2 have good in vitro antibacterial activity against Escherichia coli.

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Author Biography

Laijin Tian, Key Laboratory of Natural Products and Pharmaceutical Intermediates, Qufu Normal University, Qufu 273165, China.

Department of Chemistry

Published
2016-05-22
How to Cite
Tian, L., Shi, X., Kong, G., Liu, L., Gao, H., & GaO, X. (2016). Synthesis, characterization and antibacterial activity of cyclohexyltin N-(salicylidene)valinates. Communications in Inorganic Synthesis, 4(2). https://doi.org/10.21060/cis.v4i2.2369
Section
Artículos