1.2.2.Synthesis, crystal structure and in vitro anti-tumor activity of dibutyltin complex of 2,4-dichloro-5-fluorobenzoic acid

  • Ming Li, Liqin Wang, Zhenlei Zhang, Yue Xin, Laijin Tian

Abstract

The dibutyltin complex of 2,4-dichloro-5-

fluorobenzoic acid, [(2,4-Cl2 -5-FC6 H2 C(O)OSnBu2 )2 O]2 (Bu =

CH2 CH2 CH2 CH3 ) (1 ), has been synthesized and characterized

by elemental analysis, FT-IR, 119 Sn NMR spectroscopy, and Xray

single crystal diffraction. Compound 1 is a centrosymmetric

dimmer with two distinct types of carboxylate moieties and tin

atoms with distorted trigonal bipyramidal geometries. The in

vitro  anti-tumor activity of 1 against two human tumor cell lines

was found to be higher than that for cis-platin [cis diaminedichloroplatinum(

II)] used clinically.

Supporting information : FT-IR, 119 Sn NMR, X-Ray, Proliferation

inhibitory rate, Cif file.

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How to Cite
Yue Xin, Laijin Tian, M. L. L. W. Z. Z. (1). 1.2.2.Synthesis, crystal structure and in vitro anti-tumor activity of dibutyltin complex of 2,4-dichloro-5-fluorobenzoic acid. Communications in Inorganic Synthesis, 1(2). https://doi.org/10.21060/cis.v1i2.1998
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