1.1.4. Synthesis and characterization of some sulfadrugs azodyes, potentiometric studies of the synthesized dyes and their Fe (III) complexes.

Aida L. EL.Ansary, Hussein M. Abd El-Fattah, Nora S. Abdel-Kader and Aya M. Farghaly

Abstract


New sulfa drugs azo dyes (HL1, HL2, HL3, HL4 and HL5) were prepared by the coupling of 6-formyl-7-hydroxy-5-methoxy-2-methylbenzopyran-4-one with the sulfa drugs (sulfadiazine, sulfapyridine, sulfamethoxazole, sulfadimidine, sulfathiazole). The five prepared ligands were characterized by elemental analysis, infrared, mass spectra, and 1H-NMR spectra.  The ionization constants of the ligands and stability constants of their Fe (III) complexes were determined potentiometrically in ethanol-water media at 25°C. HL1 ligand has two pKa values while the other ligands (HL2, HL3, HL4 and HL5) have one pKa value. All the ligands form 1:1 metal chelates.

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